Engrailed and polyhomeotic maintain posterior cell identity through cubitus-interruptus regulation
نویسندگان
چکیده
منابع مشابه
engrailed and polyhomeotic interactions are required to maintain the A/P boundary of the Drosophila developing wing.
Engrailed is a nuclear regulatory protein with essential roles in embryonic segmentation and wing morphogenesis. One of its regulatory targets in embryos was shown to be the Polycomb group gene, polyhomeotic. We show here that transheterozygous adult flies, mutant for both engrailed and polyhomeotic, show a gap in the fourth vein. In the corresponding larval imaginal discs, a polyhomeotic-lacZ ...
متن کاملpolyhomeotic controls engrailed expression and the hedgehog signaling pathway in imaginal discs
Polycomb group (PcG) genes maintain cell identities during development in insects and mammals and their products are required in many developmental pathways. These include limb morphogenesis in Drosophila melanogaster, since PcG genes interact with identity and pattern specifying genes in imaginal discs and clones of polyhomeotic (ph) null cells induce abnormal limb patterning. Such clones are ...
متن کاملRoadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.
The final step in Hedgehog (Hh) signal transduction is post-translational regulation of the transcription factor, Cubitus interruptus (Ci). Ci resides in the cytoplasm in a latent form, where Hh regulates its processing into a transcriptional repressor or its nuclear access as a transcriptional activator. Levels of latent Ci are controlled by degradation, with different pathways activated in re...
متن کاملMolecular mechanism of polyhomeotic activation by Engrailed.
The Drosophila Engrailed homeoprotein has been shown to activate directly a Polycomb-group gene, polyhomeotic, during embryogenesis. The molecular mechanism involved in this activation has been studied. Two different types of Engrailed-binding fragments have been detected within the polyhomeotic locus. The P1 and D1 fragments contain several 'TTAATTGCAT' motifs, whereas the D2 fragment contains...
متن کاملThe Interaction of Mutants Affecting Venation in Drosophila Melanogaster. I. Interaction of Hairless, Engrailed and Cubitus Interruptus.
N E approach to the problem of how genes manifest themselves in develop0 ment has involved the analysis of the effects of changes at a given gene locus, such changes taking the form of alterations in the combination, dosage and position of alleles. Except where the analysis of modifier action is involved, the emphasis of this type of study is on the effects of a disturbance in the normal genoty...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2004
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2004.05.020